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Yara Sheeni | Shekh-Ahmad Lab

Yara Sheeni

There are specific studies that need to be conducted before researchers move forward with human clinical trials. Pharmacokinetics (what happens to a drug from the time it is administered to the moment it is eliminated from the body) and pharmacodynamics (what a drug does to the body - biochemical, physiologic, and molecular effects) can play an important role in pre-clinical testing. Besides pharmacodynamics, we are also studying the pharmacokinetics properties (Absorption, Distribution, Metabolism, and Excretion) of different drugs that helps in adjusting dosage, enhancing efficacy, and decreasing toxicity. This PK/PD analysis combines the two pharmacologic disciplines of pharmacokinetics and pharmacodynamics to describe the dose–concentration–response time course that is especially useful for drug development.