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Sereen Sandouka | Shekh-Ahmad Lab

Sereen Sandouka

Evaluation of expression of Nrf2 in experimental epilepsy models.

Epilepsy is one of the most common and disabling neurological disorder affecting over 65M people worldwide. Currently the available medications are prescribed to treat the symptoms of the disease while the core of the illness remains perplexed dilemma.

Common sequelae occur following a brain insult that have been shown to contribute to neuronal death and the development of epilepsy are generation of reactive oxygen species (ROS) and induction of oxidative stress which is thought to be an important pathogenic factor if not the major reason in occurrence of epilepsy. 

Recently, numerous studies are focusing on the transcription factor nuclear factor erythroid 2 related factor 2 (Nrf2) signaling pathway as an important target in protecting against oxidative stress- induced damage in a wide range of diseases, including epilepsy, through increasing the antioxidant defenses of cells . Herein, our main goal is to study the antioxidant effect of Nrf2 pathway at different epilepsy models. And following pharmacological activation of it.