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Rhoda Olowe | Shekh-Ahmad Lab

Rhoda Olowe

​I am Rhoda Olowe- a PhD student whose avidity for providing a possible solution to epilepsy, drove into the study of epilepsy disease, following my experience with a colleague battling epilepsy. I am currently looking into the role of Sestrins and the mechanisms underlying their antioxidant effects in experimental epilepsy models, with the aim to provide novel insights into the protective role of sestrin in epilepsy as well as its regulatory pathways involving the P62 dependent autophagic degradation of Keap1, attenuation of mTORC1 activity and consequent activation of Nrf2. Understanding how these pathways individually and collectively operate to activate the cellular antioxidant events may provide novel therapeutic treatment strategies that can translate into patient's trials to prevent epileptogenesis.