The Shekh-Ahmad’s lab focuses on investigating the implication of oxidative stress and reactive oxygen species (ROS) production from epileptogenic phase, through to the establishment of epilepsy in experimental models. Our lab seeks to develop antioxidant therapies capable of slowing down/inhibiting excessive ROS production implicated in the pathogenesis of the disease by elucidating several modulatory targets including genes and protein towards the development of therapeutic treatment in epilepsy. To achieve these, our lab employs a multidisciplinary, multi-level experimental approaches ranging from state-of-the-art molecular biology (including gene therapy, genetic engineering) and cutting-edge methods involving live cell imaging of cortical/hippocampal neuronal cultures, to sophisticated electrocorticography (ECoG) seizure monitoring in animal models, as well as  in vivo live imaging in freely behaving animals.   read more